Karla Souza to Lead New Grey’s Anatomy Spinoff

Souza will play Dr. Carolina “Lina” Hall, a physician in her 40s who oversees a clinic in a small West Texas town. The character is described as haunted and cynical. The center serves as a crucial source of care in a remote area, according to the series’ premise. Souza is the first actor announced for the show.

The project was initially intended for the 2026–27 broadcast season, but its schedule shifted after it failed to secure a California television tax credit. The series is in pre-production and is expected to film in Albuquerque, New Mexico, with production anticipated to start around February or March 2027.

Shonda Rhimes and current Grey’s Anatomy showrunner Meg Marinis created the spinoff and are executive producers. Grey’s Anatomy star Ellen Pompeo and Betsy Beers are also executive producers. The series is produced by 20th Television and Shondaland.

Souza previously played Laurel Castillo on ABC’s How to Get Away with Murder and appeared in the network’s Home Economics. Her other credits include Netflix’s Day Shift and Prime Video’s 56 Days and La Caida.

The new series will be the franchise’s third television spinoff, following Private Practice and Station 19. Its planned 2027–28 debut comes as the franchise enters a new chapter with its first series set to film outside Los Angeles.